P-glycoprotein相关论文
Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat br
Breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) are co-located at blood-brain barrier (BBB) cells,prev......
肿瘤细胞高表达P糖蛋白(P-gp)会抑制化疗的疗效,导致肿瘤耐药,而P-gp抑制剂可逆转P-gp介导的肿瘤耐药.辣椒素是辣椒的主要活性成分......
Effects of Jianpi Jiedu Recipe(健脾解毒方) on Reversion of P-Glycoprotein-Mediated Multidrug Resistance t
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Efficacy of Aidi Injection(艾迪注射液) on Overexpression of P-Glycoprotein Induced by Vinorelbine and Cis
Objective:To investigate the efficacy of Aidi Injection(艾迪注射液) on overexpression of P-glycoprotein (P-gp) induced b......
Polymer inhibitors of ABC transporter overcoming multidrug resistance:synthesis,characterization and
One of the most significant problems of chemotherapy is that even originally very sensitive tumors become often resistan......
Polymer inhibitors of ABC transporter overcoming multidrug resistance: synthesis,characterization an
One of the most significant problems of chemotherapy is that even originally very sensitive tumors become often resistan......
Chitosan-Modified PLGA Nanoparticles as Drug Delivery Carrier for Modulating P-Glycoprotein of Enter
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The aim of this study was to analyze the influence of permeability glycoprotein (P-gp) expression on enrofloxacin (ENR) ......
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Doxorubicin (DOX) is a widely used chemotherapeutic drug for the treatment of several types of cancers.However,its side ......
Study on the relationship between P-glycoprotein and Abamectin resistance in Tetranychus cinnabarinu
Tetranychus cinnabarinus is one of the most harmful crop mite pests.Owing to its strong reproductive ability,short life ......
P-glycoproteinoverexpressioninBoneMarrowMesenchymalcelldecreasesthesteroid-inducedosteonec
This study was to investigate the efficacy of P-glycoprotein(P-gp)overexpression on bone marrow mesenchymal cell(BMSC)os......
Rifampicin was reported to decrease the risk of steroid-induced osteonecrosis of the femoral head(ONFH),however,the prec......
Association between P-Glycoprotein expression and response to chemotherapy in patients with osteosar
Objective:The aim was to investigate the association between p-glycoprotein(Pgp)expression and response to chemotherapy ......
Aim: Aconitine (AC) is a toxic alkaloid from some Chinese medicinal herbals with origin of genus Aconitum, which have be......
Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both pa
Aim: Blood brain barrier (BBB) dysfunction is a common facet of cerebral ischemia, and the alteration of drug transporte......
In order to examine the effect of capsaicin in the regulation of P-gp substrate rhodamine 123(R123)across the intestinal......
Introduction: Monolayers of Caco-2 cells have been widely accepted as one of the well-established in vitro models to pre......
Absorption characteristic of Paeoniflorin-6′O-benzene sulfonate in an situ single-pass intestinal pe
Aim Paeoniflorin6′ Obenzene sulfonate (CP25) was synthesized to improve oral absorption.This study was performed to inv......
Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: an insight into
Ain The present study developed a CYP3A4expressed Caco2 monolayer model at which effects of the effluxmetabolism allianc......
In situ rat intestine absorption of total Anthraquinone of Polygonum cuspidatum solid lipid nanopart
Objective:To study the rat intestinal absorption characteristic of archen and emodin monomethyl ether of the total anthr......
To search for better P-glycoprotein-(Pgp-)mediated multidrug resistance(MDR)modulators,we designed and synthesized a ser......
Platelet activating factor mediates blood brain barrier dysfunction through up-regulation of MMP-9 i
Platelet-activating factor (PAF) was a lipid mediator that aggravated brain injury after cerebral ischemia and reperfusi......
Pluronic P123 micelle drug delivery system loading Itraconazole:development, evaluation and its effe
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Microbial transformation of diosgenin by Cunninghamella blakes leana AS3.970and potential inhibitory
Microbial transformation of diosgenin((25R)-spirost-5-en-3β-ol)using Cunninghamella blakesleana AS 3.970,afforded eleve......
Food emulsifier glycerin monostearate enhances phthalates’ male reproductive toxicity to rats follow
Human beings are inevitably exposed to ubiquitous phthalates(PEs)surroundings,and simultaneously ingesting a plenty of f......
P-glycoprotein (P-gp) is believed to mediate multidrug resistance (MDR) by acting as efflux pump to actively transport c......
Targeting autophagy augments the activity of dihydroptychantol A derivative to overcome p-gp mediate
we have previously found that dihydroptychantol A (DHA) is capable of modulating the function of P-glycoprotein (P-gp) a......
Multifunctional Nanoassemblies of Doxorubicin Overcome Multidrug Resistance and Improve Oral Absorpt
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Effets of JianpiJieduRecipeonReversion of P-glycoprotein-mediated Multidrug Resistance through COX-2
To evaluate the underlying mechanism of JianpiJiedu Recipe(健脾解毒方, JJR) in the reversion of multidrug resistance con......
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Comparison of antileukemic immunity mediated by dendritic cells derived from multidrug resistant leu
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Overexpression of glucosylceramide synthase and its significance in the clinical outcome of non-smal
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Multidrug resistance(MDR)is a serious obstacle encountered in cancer treatment.This study was performed to explore the r......
目的探讨谷氨酰胺酶2(GLS2)对肝胆管癌细胞5-氟尿嘧啶(5-Fu)化疗敏感性的作用及其机制。方法TIMER数据库检索GLS2在泛癌中表达水平......
Alantolactone,a sesquiterpene lactone component of roots of Anula helenium has been reported to exhibit anticancer a......
Multidrug resistance (MDR) caused by human ABCB1 (P-glycoprotein /MDR1) is one of the major obstacles in chemotherapy.To......
采用实时荧光定量PCR方法研究缢蛏暴露于苯并芘三组浓度下(0.06ug/L,0.12ug/L,0.24ug/L)的P4501A1和P-gp基因表达量.结果表明P......
The effects of guggulsterone on P-glycoprotein efflux activity at blood-brain barrier in vitro and i
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P-糖蛋白(P-glycoprotein,P-GP)作为机体重要的药物外排转运体,广泛分布于肠道黏膜上皮细胞刷状缘、肝细胞膜胆管面、肾近曲小......
目的：观察设计构建的苯妥英钠纳米粒(P85-PHT-PBCA-NPs)能否避开PHT耐药性颞叶内侧癫痫模型血脑屏障上P糖蛋白(P-glycoprotein,......
目的探讨银杏叶提取物(ginkgo biloba extracts，EGb761)对血管性痴呆(vascular dementia，VD)大鼠学习记忆的影响及海马神经元的保护......
Dynamic expression of P-glycoprotein in the CA1,CA3 and dentate gyrus of the rat hippocampus followi
Epileptic seizures induce overexpression of P-glycoprotein in the blood-brain barrier. However, it is unclear whether hi......
